Modulation of connexin43 alters expression of osteoblastic differentiation markers
نویسندگان
چکیده
منابع مشابه
Modulation of connexin43 alters expression of osteoblastic differentiation markers.
Gap junctional channels between cells provide a pathway for exchange of regulatory ions and small molecules. We previously demonstrated that expression of connexins and cell-to-cell communication parallel osteoblastic differentiation and that nonspecific pharmacological inhibitors of gap junctional communication inhibit alkaline phosphatase activity. In this study, we stably transfected connexi...
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Canonical Wnt signaling activates miR-34 expression during osteoblastic differentiation.
The canonical Wnt signaling pathway is crucial for the regulation of bone mass in humans and for the development of osteoblasts. MicroRNAs (miRs) represent a class of non‑coding RNAs, ~22 nucleotides in length, that regulate gene expression by targeting mRNAs for cleavage or translational repression. Several previous studies have demonstrated the involvement of miRNAs in modulating gene express...
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Background and Aim: Different regulation processes have an effect on osteoblastic differentiation of mesenchymal stem cells (MSCs), and among them Wnt signaling pathway is particularly desirable. In Wnt signaling pathway, Adenomatous Polyposis Coli (APC) bind to β-catenin and induce its degradation, thereby acting as a negative regulator of canonical Wnt pathway. In this study, gene expression ...
متن کاملConnexin43 reverses the phenotype of transformed cells and alters their expression of cyclin/cyclin-dependent kinases.
Communication between adjacent cells through gap junctions is believed to be involved in the regulation of cell proliferation. This stems in part from the observation that transfection and overexpression of connexin (cx) 32 or cx43 genes into neoplastic cells lead to normalization of growth and decrease their tumorigenicity. The molecular mechanism(s) responsible for this phenomenon has not bee...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2006
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00428.2005